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Accueil > Integrative Biological Chemistry Platform (Pascal Villa)(UMS 3236) > Introduction > Platform of Integrative Chemical Biology of Strasbourg UMS 3286

Platform of Integrative Chemical Biology of Strasbourg UMS 3286

Head: Pascal VILLA

Introduction
Starting from biological targets (cells, proteins, nucleic acids, ...), the Platform of Integrative Chemical Biology is able to set up specific high throughput screening in accordance with the associated composed problem and then to making out at high throughput its chemical and/or natural libraries or the molecules furnished in respect to Quality Management System.

High Throughput Screening

  • Automated High Throughput screening
  • > 6000 measurements per day (fluorescence, anisotropy, HTRF, FRET, luminescence, BRET, absorbance)
  • Development of pharmacological tests
  • In vitro molecular tests (ligand - receptor, enzymatic tests...)
  • Cellular tests on bacteria or eucaryotic cells (liberation of soluble factors, cytokines, cellular survey, apoptosis, toxicity...)
  • Provision of devices (microplate readers, liquid handlers...)

Biological Targets Libraries

  • Development of pharmacological tests
  • Validation of therapeutic targets (GPCRs, kinases, etc.)
  • Cloning, expression and protein production
  • Provision of tissue culture room with devices

Chemical/Natural Libraries

  • A collection of more than 6000 molecules (chemicals or naturals)
  • Database management (MDL ISIS/Base) an

 

 

Adress :

Plate-forme de chimie biologique intégrative de Strasbourg (PCBIS)
Unité mixte de service CNRS - Université de Strasbourg (UMS 3286)

Institut de recherche de l’École de biotechnologie de Strasbourg et Faculté de pharmacie
ESBS - Pôle API
300, Bld Sébastien Brant CS10413
67412 ILLKIRCH Cedex - France
Tél. : +33 (0)3 68 85 48 71
Fax : +33 (0)3 68 85 44 15
Contact : pvilla@unistra.fr