Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins mediated by poly(ADP-ribose) polymerases (PARPs), a family of 17 proteins. Among them, PARP-1 and PARP-2, the most studied in the family, are now recognized as key proteins in genome stability.
Recent work of the team headed by Françoise Dantzer and Valérie Schreiber describes another PARP family protein, PARP-3, as a new player in the cellular response to DNA double-strand breaks and a critical regulator of mitotic progression in which it controls dynamics of the mitotic spindle and integrity of telomeres.
These results, published in a recent PNAS issue, reveal that PARP-3 might be a promising new target in cancer therapy.
This work has been highlighted by a special report on the CNRS website : "News from the labs" [french].
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