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Accueil > Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242)
> Introduction > The scientific objectives

UMR 7242 - Biotechnology and cell signaling: genome integrity, tumor biology, receptors, therapeutic tools

The scientific objectives

The scientific choices made at UMR 7242 - a CNRS and University of Strasbourg operated research unit - rely on the expertise of the local School of Biotechnology (ESBS), and the nearby Faculty of Pharmacy and IGBMC, as well as the global scientific strategy at the Illkirch campus: chemical and structural genomics.

Research conducted at UMR 7242 is at the junction of several approaches: integrative biology (homologous recombination in mice and related phenotyping), biological chemistry (screening of chemicals collections and development of potentially therapeutic pharmacological tools) and biotechnology. The access to highly performant technological platforms operated by the three Institutes at the Illkirch campus of is undoubtedly a great benefit.

The research teams combine molecular biology approaches, small molecule chemistry and structural biology to decrypt the signaling pathways and study their regulation, in order to understand cellular functions and intercellular communication.

Cooperation with other teams at the Illkirch campus and research at the interface of disciplines are a priority, and scientific animation is carried out jointly on the site in order to generate frequent exchanges. The technical facilities of the unit are open to all the local community (including private companies), regardless of origin.

The study of cell signaling is changing for several years. Knowledge of genomes, the new biotechnological and chemical tools for gene expression and protein function, the new methods for measuring protein - protein interactions allow researchers to explore more rapidly and efficiently the value chain going from the gene to the whole animal.

The two major scientific problems we are interested in are:

  • behavior of genomes to changes in chemical, biological or physical environment, and their response in terms of repair, transcriptional activity or damage leading to carcinogenesis;
  • signal transduction or material transduction on both sides of the cell membrane, and the regulation of these processes.

These issues are the central themes of the two departments entitled " Genome integrity and tumor biology " and " Receptors, membrane proteins and therapeutic innovation ".

 

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