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Chirality and life chemistry

September 15, 2011

Researchers from the team "Membrane transport in bacteria" at the Biotechnology and Cell Signaling research unit (UMR 7242) showed using in vitro and in vivo functional studies, that recognition and transport of siderophores by their specific receptors are highly enantioselective.

In collaboration with Dr. David Cobessi (Institute of Structural Biology, Grenoble) and Dr. Didier Rognan (UMR 7200 CNRS / University of Strasbourg), they solved the three-dimensional structures of siderophore-receptor complexes from two different bacteria of the Pseudomonas family. These structures allowed them to reveal the structural basis for enantioselective recognition between two enantiomer siderophores and their respective receptors.