Logo Université de Strasbourg


Sur ce site

Sur le Web du CNRS

Accueil > Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242)
> Genome integrity and tumor biology (Scientific coordination : Valérie Schreiber) > Poly(ADP-ribosyl)ation and genome integrity (Françoise Dantzer and Valérie Schreiber) > Publications > Publications of the team Poly(ADP-ribosyl)ation and genome integrity

Publications of the team Poly(ADP-ribosyl)ation and genome integrity

Updated : September 30, 2016

2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 |


- Back to the team home page


- 2016

Martin-Hernandez K, Rodriguez-Vargas JM, Schreiber V, Dantzer F.
Expanding functions of ADP-ribosylation in the maintenance of genome integrity.
Semin Cell Dev Biol. 2016 (16)30298-1DOI

Karicheva O, Rodriguez-Vargas JM, Wadier N, Martin-Hernandez K, Vauchelles R, Magroun N, Tissier A, Schreiber V, Dantzer F.
PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.
Oncotarget. 2016 Aug 26 - DOI

Noll A, Illuzzi G, Amé J-C, Dantzer F, Schreiber V
PARG de ciency is neither synthetic lethal with BRCA1 nor PTEN deciency
Cancer Cell Int (2016) 16:53 - DOI

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC
Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.
Erratum in J Biol Chem. 2016, 291(10):4873-81 - DOI

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC
Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.
J Biol Chem. 2016, 291(17):9382 - DOI

Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M
A PARP1-ERK2 synergism is required for the induction of LTP.
Sci Rep. 2016, 6:24950 - DOI

Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C
Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.
Cancer Lett. 2016, 374(2):208-15 - DOI

Top of page


- 2015

Kutuzov MM, Khodyreva SN, Ilina ES, Sukhanova MV, Amé JC, Lavrik OI
Interaction of PARP-2 with AP site containing DNA.
Biochimie. 2015 May;112:10-9 - DOI

Schreiber V, Illuzzi G, Héberlé E, Dantzer F
From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy.
Bull Cancer. 2015 Oct;102(10):863-73 - DOI

Robert I, Gaudot L, Rogier M, Heyer V, Noll A, Dantzer F, Reina-San-Martin B
Parp3 negatively regulates immunoglobulin class switch recombination.
PLoS Genet. 2015 May 22;11(5):e1005240 - DOI

Farrés J, Lacune L, Martin-Caballero J, Martínez C, Lozano J J, Ampurdanés C, López-Contreras A J, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O and Yélamos J
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Cell Death & Differentiation, 2015, 22, 1144-1157 - DOI

Schreiber, V., Illuzzi, G., Héberlé, E., and Dantzer, F.
From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy.
Bull Cancer, 2015, 102, 863–873 - DOI

Robert, I., Gaudot, L., Rogier, M., Heyer, V., Noll, A., Dantzer, F., and Reina-San-Martin, B.
Parp3 negatively regulates immunoglobulin class switch recombination.
PLoS Genet., 2015, 11, e1005240 - DOI.

Top of page


- 2014
Beck C, Robert I, Reina-San-Martin B, Schreiber V, Dantzer F.
Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3.
Exp Cell Res. 2014 15, 18-25 - DOI

Illuzzi G, Fouquerel E, Amé JC, Noll A, Rehmet K, Nasheuer HP, Dantzer F, Schreiber V.
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.
Nucleic Acids Res. 2014 15, 18-25 - DOI

Kutuzov MM, Khodyreva SN, Schreiber V, Lavrik OI
The role of PARP2 in DNA repair.
Mol Biol (Mosk). 2014 Jul-Aug;48(4):561-72. Review. Russian.

Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M.
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Cell Metab. 2014 19, 1042-1049 - DOI

De Vos M, El Ramy R, Quénet D, Wolf P, Spada F, Magroun N, Babbio F, Schreiber V, Leonhardt H, Bonapace IM, Dantzer F.
Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions.
J Biol Chem. 2014 6, 16223-16238 - DOI

Beck C, Boehler C, Guirouilh Barbat J, Bonnet ME, Illuzzi G, Ronde P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin FD, Schreiber V, Dantzer F.
PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.
Nucleic Acids Res. 2014 42, 5616-5632 - DOI

Top of page


- 2013

Castiel A, Visochek L, Mittelman L, Zilberstein Y, Dantzer F, Izraeli S, Cohen-Armon M.
Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.
J Vis Exp. 2013 78 - DOI

Dantzer F, Santoro R
The expanding role of PARPs in the establishment and maintenance of heterochromatin.
FEBS J. 2013 280, 3508-3518 - DOI

Kutuzov MM, Khodyreva SN, Amé JC, Ilina ES, Sukhanova MV, Schreiber V, Lavrik OI.
Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins.
Biochimie. 2013 95, 1208-1215 - DOI

Farrés J, Martín-Caballero J, Martínez C, Lozano JJ, Llacuna L, Ampurdanés C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yélamos J.
Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.
Blood. 2013 122, 44-54 - DOI

Robert I, Karicheva O, Reina San Martin B, Schreiber V, Dantzer F.
Functional aspects of PARylation in induced and programmed DNA repair processes: Preserving genome integrity and modulating physiological events.
Mol Aspects Med. 2013 34, 1138-1152 - DOI

Legrand AJ, Choul-Li S, Spriet C, Idziorek T, Vicogne D, Drobecq H, Dantzer F, Villeret V, Aumercier M.
The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.
PLoS One. 2013 8, issue 2 - DOI

Top of page


- 2012

Le May N, Iltis I, Amé JC, Zhovmer A, Biard D, Egly JM, Schreiber V, Coin F.
Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.
Mol Cell. 2012 48, 785-798. - DOI

Anjos SM, Robert R, Waller D, Zhang DL, Balghi H, Sampson HM, Ciciriello F, Lesimple P, Carlile GW, Goepp J, Liao J, Ferraro P, Phillipe R, Dantzer F, Hanrahan JW, Thomas DY.
Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking.
Front Pharmacol. 2012 3, 165 - DOI

De Vos M., Schreiber V., Dantzer F.
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.
Biochem Pharmacol. 2012 84, 137-146 - DOI

Kalisch T., Amé J.-C., Dantzer F., Schreiber V.
New readers and interpretations of poly(ADP-ribosyl)ation.
Trends Biochem Sci. 2012 37, 381-390 - DOI

Top of page


- 2011

Amé J.-C., Kalisch T., Dantzer F., Schreiber V.
Purification of recombinant poly(ADP-ribose) polymerases.
Meth. Mol. Biol. 2011 780, 135-152 - DOI

Bai P., Cantó C., Brunyánszki A., Huber A., Szántó M., Cen Y., Yamamoto H., Houten S.M., Kiss B., Oudart H., Gergely P., Ménissier-de Murcia J., Schreiber V., Sauve A.A., Auwerx J.
PARP-2 regulates SIRT1 expression and whole-body energy expenditure.
Cell. Metab. 2011, 13, 450-460 - DOI

Bai P., Cantó C., Oudart H., Brunyánszki A., Cen Y., Thomas C., Yamamoto H., Huber A., Kiss B., Houtkooper R.H., Schoonjans K., Schreiber V., Sauve A.A., Ménissier-de Murcia J., Auwerx J.
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Cell. Metab. 2011, 13, 461-468 - DOI

Boehler C., Dantzer F.
PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression.
Cell Cycle 2011, 10, 1023–1024- DOI

Boehler C., Gauthier L.R., Mortusewicz O., Biard D., Saliou J.-M., Bresson A., Sanglier-Cianferani S., Smith S., Schreiber V., Boussin F.D., Dantzer F.
PARP3, a newcomer in cellular response to DNA damage and mitotic progression.
Proc. Natl. Acad. Sci. (USA) 2011, 108, 2783-2788 - DOI

Boehler C., Gauthier L.R., Yelamos J., Noll A., Schreiber V., Dantzer F.
Phenotypic characterization of Parp-1 and Parp-2 deficient mice and cells.
Meth. Mol. Biol. 2011 ( in press)
Dantzer F, Noël G, Schreiber V
PARP inhibitors: significant progress incancer therapy.
Bull. Cancer. 2011, 98, 277-290 - DOI

Dantzer F., Noël G., Schreiber V.
PARP inhibitors: significant progress incancer therapy.
Bull. Cancer. 2011, 98, 277-290 - DOI

Mortusewicz O., Fouquerel E., Amé J.-C., Leonhardt H., Schreiber V.
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.
Nucleic Acids Res. 2011, 39, 5045-5056 - DOI

Top of page


- 2010

Brunyánszki A, Hegedus C, Szántó M, Erdélyi K, Kovács K, Schreiber V, Gergely S, Kiss B, Szabó E, Virág L, Bai P
Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress.
J. Invest. Dermatol. 2010 130, 2629-37 - DOI

Nicolas L, Martinez C, Baro C, Rodriguez M, Baroja-Mazo A, Sole F, Flores J, Ampurdanes C, Dantzer F, Martin-Cabarello J, Aparicio P, Yelamos J
Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T cell lymphomas in p53 deficient mice.
Oncogene 2010 29, 2877–2883 DOI

Tentori L, Muzi A, Dorio AS, Scarsella M, Leonetti C, Shah GM, Xu W, Camaioni E, Gold B, Pellicciari R, Dantzer F, Zhang J, Graziani G
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Curr Cancer Drug Targets. 2010 10, 368-83 PubMed

Top of page


- 2009

Ambrose H.E., Willimott S., Beswick R.W., Dantzer F., de Murcia J.M., Yelamos J., Wagner S.D
Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.
Immunology. 2009 127, 178-86 - DOI

Amé, J.-C., Fouquerel, E., Gauthier L.R., Biard B., Boussin F.D., Dantzer F., de Murcia G., Schreiber V.
Radiation-induced mitotic catastrophe in PARG-deficient cells
J. Cell Sci. 2009 122, 1990-2002 - DOI

Amé J.-C., Hakmé A., Quénet D., Fouquerel E., Dantzer F., Schreiber V.
Detection of the nuclear poly(ADP-ribose)-metabolizing enzymes and activities inresponse to DNA damage.
Methods Mol. Biol. 2009 464, 267-83 - DOI

El Ramy R., Magroun N., Messadecq N., Gauthier L.R., Boussin F.D., Kolthur-Seetharam U., Schreiber V, McBurney M.W., Sassone-Corsi P., Dantzer F.
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.
Cell. Mol. Life Sci. 2009 66, 3219-34 - DOI

Inbar-Rozensal D., Castiel A., Visochek L., Castel D., Dantzer F., Izraeli S., Cohen-Armon M.
A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.
Breast Cancer Res. 2009 11, R78 - DOI

Kotoglou P., Kalaitzakis A., Vezyraki P., Tzavaras T., Michalis L.K., Dantzer F., Jung J.U., Angelidis C.
Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks.

Cell Stress Chaperones. 2009 14, 391-406 - DOI

Lévy N., Oehlmann M., Delalande F., Nasheuer H.P., Van Dorsselaer A., Schreiber V., de Murcia G., Ménissier-de Murcia J., Maiorano D., Bresson A.
XRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may coordinate DNA repair and replication during S phase.
Nucleic Acids Res. 2009 37, 3177-88 - DOI

Martin N., Schwamborn K., Schreiber V. , Werner A., Sabatier L., Bischof O., Matunis M., Seeler J., Dejean A.
PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.
EMBO J, 2009 28, 3534-48 - DOI

Muñoz-Gámez J.A., Rodríguez-Vargas JM, Quiles-Pérez R, Aguilar-Quesada R., Martín-Oliva D., de Murcia G., de Murcia J.M., Almendros A., de Almodóvar M.R., Oliver F.J.
PARP-1 is involved in autophagy induced by DNA damage.
Autophagy 2009 5, 61-74 - PubMed

Nossa C.W., Jain P., Tamilselvam B., Gupta V.R., Chen L.-F., Schreiber V., Desnoyers S., Blanke S.R.
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Proc. Natl. Acad. Sci USA 2009 106, 19998-20003 - DOI

Quénet D., El Ramy R., Schreiber V., Dantzer F.
The role of poly(ADP-ribosyl)ation in epigenetic events.
Int. J. Biochem. Cell Biol. 2009 41, 60-5 - DOI

Quénet D, Mark M, Govin J, van Dorsselear A, Schreiber V, Khochbin S, Dantzer F.
Parp2 is required for the differentiation of post-meiotic germ cells: Identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Exp. Cell Res. 2009 315, 2824-34 - DOI

Robert I., Dantzer F., Reina-San-Martin B.
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
J. Exp. Med. 2009 206, 1047-56 - DOI

Stilmann M., Hinz M., Arslan S.C., Zimmer A., Schreiber V., Scheidereit C.
A nuclear poly(ADP-ribose) - dependent signalosome confers DNA damage induced IkB kinase activation.
Mol Cell 2009 13, 365-78 - DOI

Top of page


- 2008

Hakmé A., Huber A., Dollé P., Schreiber V.
The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.
Dev. Dyn. 2008 237, 209-15 - DOI

Hakmé A., Wong H.K., Dantzer F. and Schreiber V.
The expanding field of poly(ADP-ribosyl)ation reactions. ’Protein modifications: beyond the usual suspects’ - Review series.
EMBO Rep. 2008 9, 1094-100 - DOI

Pagès V., Bresson A., Acharya N., Prakash S., Fuchs R.P., Prakash L.
Requirement of Rad5 for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiae.
Genetics. 2008 180, 73-82 - DOI

Quénet D., Gasser V., Fouillen L., Cammas F., Sanglier-Cianferani S., Losson R., Dantzer F.
The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1-beta and the heterochromatin protein HP1-alpha
FASEB J. 2008 22, 3853-65 - DOI

Valdor R., Schreiber V., Saenz L., Martínez T., Muñoz-Suano A., Dominguez-Villar M., Ramírez P., Parrilla P., Aguado E., García-Cózar F., Yelamos J.
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.
Mol. Immunol. 2008 45, 1863-71 - DOI

Yelamos J., Schreiber V., Dantzer F.
Towards specific functions of poly(ADP-ribose) polymerase-2.
Trends Mol. Med. 2008 14, 169-78 - DOI

Top of page


- 2007

Aguilar-Quesada R., Munoz-Gamez J.A., Martin-Oliva D., Peralta A., Valenzuela M.T., Matinez-Romero R., Quiles-Perez R., Ménissier-de Murcia J., de Murcia G., de Almodovar M.R., Oliver F.J.
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.
BMC Mol. Biol. 2007 8, 29 - DOI

Bai P., Houten S.M., Huber A., Schreiber V., Watanabe M., Kiss B., de Murcia G., Auwerx J., Ménissier-de Murcia J.
Poly(ADP-ribose) polymerase-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma heterodimer.
J. Biol. Chem. 2007 282, 37738-46 - DOI

Gueven N., Bécherel O.J., Howe O., Chen P., Haince J.F., Ouellet M.E., Poirier G.G., Waterhouse N., Fusser M., Epe B., Ménissier-de Murcia J., de Murcia G., McGowan C.H., Parton R., Mothersill C., Grattan-Smith P., Lavin M.F.
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance.
Cell Death Differ. 2007 14 ,1149-61 - DOI

Mortusewicz O., Amé J.C., Schreiber V., Leonhardt H.
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.
Nucleic Acids Res. 2007 5, 7665-75 - DOI

Moubarak R.S., Yuste V.J., Artus C., Bouharrour A., Greer P.A., Ménissier-de Murcia J., Susin S.A.
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.
Mol. Cell. Biol. 2007 27, 4844-62 - DOI

Top of page


- 2006

Becherel, O.J., N. Gueven, G.W. Birrell, V. Schreiber, A. Suraweera, B. Jakob, G. Taucher-Scholz, M.F. Lavin
Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription.
Hum. Mol. Genet. 2006 15, 2239-49

Dantzer, F., J.C. Amé, V. Schreiber, J. Nakamura, J. Ménissier-de Murcia, G. de Murcia
Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair.
Methods Enzymol. 2006 409, 493-510

Dantzer, F., M. Mark, D. Quénet, H. Scherthan, A. Huber, B. Liebe, L. Monaco, A. Chicheportiche, P. Sassone-Corsi, G. de Murcia, J. Ménissier-de Murcia
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis.
Proc. Natl Acad. Sci USA 2006 103, 14854-9

Gomez, M., J. Wu, V. Schreiber, J. Dunlap, F. Dantzer, Y. Wang, Y. Liu
PARP1 is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
Mol. Biol. Cell 2006 17, 1686-96

Hochegger, H., D. Dejsuphong, T. Fukushima, C. Morrison, E. Sonoda, V. Schreiber, G.Y. Zhao, A. Saberi, M. Masutani, N. Adachi, H. Koyama, G. de Murcia, S. Takeda
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.
EMBO J. 2006 25, 1305-14

Kolthur-Seetharam, U., F. Dantzer, M.W. McBurney, G. de Murcia, P. Sassone-Corsi
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.
Cell Cycle 2006 5, 873-7

Lévy, N., A. Martz, A. Bresson, C. Spenlehauer, G. de Murcia and J. Ménissier-de Murcia
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.
Nucleic Acids Res. 2006 34, 32-41

Maeda, Y., T.C. Hunter, D.E. Loudy, V. Dave, V. Schreiber, J.A. Whitsett
PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.
J. Biol. Chem. 2006 281, 9600-6

Schreiber, V., F. Dantzer, J.C. Amé, G. de Murcia
Poly(ADP-ribose): novel functions for an old molecule.
Nat. Rev. Mol. Cell. Biol. 2006 7, 517-28.

Yelamos, J., Y. Monreal, L. Saenz, E. Aguado, V. Schreiber, R. Mota, T. Fuente, A. Minguela, P. Parrilla, G. de Murcia, E. Almarza, P. Aparicio and J. Ménissier-de Murcia
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.
EMBO J. 2006 25, 4350-60.

Top of page


- 2005

Carrillo, A., Y. Monreal, P. Ramirez, E. Suarez, P. Parrilla, J. Ménissier-de Murcia, G. de Murcia, L. Alvarez-Vallina, J. Yelamos
Establishment of an immortalized PARP-1-/- murine endothelial cell line: a new tool to study PARP-1 mediated endothelial cell dysfunction.
J. Cell Biochem. 2005 94, 1163-74

Luna, L., V. Rolseth, G.A. Hildrestrand, M. Otterlei, F. Dantzer, M. Bjoras, E. Seeberg
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant.
Nucleic Acids Res. 2005 33, 1813-24

Meder, V.S., M. Boeglin, G. de Murcia, V. Schreiber
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli.
J. Cell Sci. 2005 118, 211-22

Monaco, L., U. Kolthur-Seetharam, R. Loury, J.M. Murcia, G. de Murcia, P. Sassone-Corsi
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage.
Proc. Natl Acad. Sci USA 2005 102 14244-8

Munoz-Gamez, J.A., D. Martin-Oliva, R. Aguilar-Quesada , A. Canuelo, M.I. Nunez, M.T. Valenzuela, J.M. Ruiz De Almodovar, G. De Murcia, F.J. Oliver
PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.
Biochem. J., 2005 386, 119-125

Pavri, R., B. Lewis, T.-K. Kim, F.J. Dilworth, H. Erdjument-Bromage, P. Tempst, _ G. De Murcia, R. Evans, P. Chambon and D. Reinberg
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of Mediator.
Molecular Cell 2005 18, 83-96

Pion, E., G.M. Ullmann, J.C. Amé, D. Gérard, G. de Murcia, E. Bombarda
DNA-induced dimerization of poly(ADP-ribose) polymerase-1 triggers its activation.
Biochemistry 2005 44, 14670-81

Spenlehauer, C., Pion, E., Tartier, L., Amé, J.-C., Dantzer, F., Schreiber, V., Gradwohl, G., Ménissier-de Murcia, J., de Murcia, G.
DNA strand breaks recognition, signaling and resolution : the role of poly(ADP-ribose) polymerases-1 and -2.
2005 Siede Editor, Marcel Dekker Inc, NY

Top of page


- 2004

Amé, J.C., C. Spenlehauer, G. de Murcia
The PARP superfamily.
Bioessays 2004 26, 882-93

Dantzer, F., M.J. Giraud-Panis, I. Jaco, J.C. Amé, I. Schultz, M. Blasco, C.E. Koering, E. Gilson, J. Ménissier-de Murcia, G. de Murcia, V. Schreiber
Functional interaction between poly(ADP-ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.
Mol. Cell. Biol. 2004 24, 1595-607

Espejel, S., P. Klatt, J. De Murcia, J. Martin-Caballero, J.M. Flores, G. De Murcia, M.A. Blasco
Abrogation of Ku86 and DNA-PKcs, and to a lesser extend of PARP-1, accelerate organismal aging caused by progressive telomere shortening in telomerase-deficient mice.
J. Cell Biol 2004 167, 627-638

Huber, A., P. Bai, J.M. de Murcia, G. de Murcia
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development.
DNA Repair (Amst) 2004 3, 1103-8

Oliver, A.W., J.C. Amé, S.M. Roe, V. Good, G. de Murcia, L.H. Pearl
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.
Nucleic Acids Res. 2004 32, 456-64

Schreiber, V., Ricou, M., Amé, J.-C., Dantzer, F, Meder V., Spenlehauer, C., Stiegler, P., Niedergang, C., Sabatier, L., Favaudon, V., Ménissier-de Murcia, J., de Murcia, G.
PARP-2: structure-function relationship.
Poly(ADP-ribosyl)ation reactions 2004 Burkle A. Edit. Landes

Von Kobbe, C., J.A. Harrigan, V. Schreiber, P. Stiegler, J. Piotrowski, L. Dawut, V.A. Bohr
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Nucleic Acids Res. 2004 32, 4003-14

Top of page


- 2003

Augustin, A., C. Spenlehauer, H. Dumond, J. Ménissier-De Murcia, M. Piel, A.C. Schmit, F. Apiou, J.L. Vonesch, M. Kock, M. Bornens, G. De Murcia
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.
J. Cell Sci. 2003 116, 1551-62

Dantzer, F., M. Bjoras, L. Luna, A. Klungland, E. Seeberg
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells.
DNA Repair (Amst) 2003 2, 707-18

Le Page, F., V. Schreiber, C. Dherin, G. De Murcia, S. Boiteux
Poly(ADP-ribose) polymerase-1 (PARP-1) is required in murine cell lines for base excision repair of oxidative DNA damage in the absence of DNA polymerase beta.
J. Biol. Chem. 2003 278, 18471-7

Marsin, S., A.E. Vidal, M. Sossou, J. Ménissier-de Murcia, F. Le Page, S. Boiteux, G. de Murcia, J.P. Radicella
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.
J. Biol. Chem. 2003 278, 44068-74

Ménissier de Murcia, J., M. Ricoul, L. Tartier, C. Niedergang, A. Huber, F. Dantzer, V. Schreiber, J.C. Amé, A. Dierich, M. LeMeur, L. Sabatier, P. Chambon, G. de Murcia
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.
EMBO J. 2003 22, 2255-63

Nakamura, J., S. Asakura, S.D. Hester, G. de Murcia, K.W. Caldecott, J.A. Swenberg
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time.
Nucleic Acids Res. 2003 31, e104

Pion, E., E. Bombarda, P. Stiegler, G.M. Ullmann, Y. Mély, G. de Murcia, D. Gérard
Poly(ADP-ribose) polymerase-1 dimerizes at a 5’ recessed DNA end in vitro: a fluorescence study.
Biochemistry 2003 42, 12409-17

Tartier, L., C. Spenlehauer, H.C. Newman, M. Folkard, K.M. Prise, B.D. Michael, J. Ménissier-de Murcia, G. de Murcia
Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.
Mutagenesis 2003 18, 411-6

Top of page


- 2002

Benchoua A., Couriaud C., Guégan C., Tartier L., Couvert P., Friocourt G., Chelly J., Ménissier-de Murcia J., Onténiente B.
Active caspase-8 translocates in nucleus of apoptotic cells to inactivate poly(ADPribose) polymerase-2.
J. Biol. Chem. 2002 277 34217-34222

Gonzales C., Ménissier de Murcia J., Janiak P.H., Bidouard J.-P., Beauvais C., Karray S., Garchon H.-J., Levi-Strauss M.
Unexpected sensitivity of non obese diabetic mice with a disrupted poly(ADP-ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.
Diabetes 2002 51, 1470-14765

Lee D., Kim J.W., Kim K., Joe C.O., Schreiber V., Ménissier-de-Murcia J., Choe J.
Functional interaction between human papillomavirus type 18 E2 and poly(ADP-ribose) polymerase-1.
Oncogene 2002 21, 5877-5885

Schreiber V., Amé J.-C., Dollé P., Schultz I., Rinaldi B., Fraulob V., Ménissier-de Murcia J., de Murcia G.
PARP-2 is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
J. Biol. Chem. 2002 277, 23028-23036

Top of page


- 2001

Conde C., Mark M., Oliver F.J., Huber A., de Murcia G., Ménissier-de Murcia J.
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice.
EMBO J. 2001 20, 3535-3543

Ménissier-de Murcia J., Mark M., Wynshaw B.A., de Murcia G.
Early embryonic lethality in PARP-1 ; Atm double mutant mice suggests a functional synergy in cell proliferation during development.
Mol. Cell. Biol. 2001 21, 1828-1832

Pereira C.A., Pouliquen Y., Rodas V., Massotte D., Mortensen C.S., Ménissier de Murcia J.
Optimized insect cell culture for the production of recombinant heterologous proteins and baculovirus.
BioTechniques 2001 31, 1262-1268

Samper E., Goytisolo F.A., Ménissier-de Murcia J., González-Suárez E., de Murcia G., Blasco M.A.
Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-1 deficient mice and primary cells despite increased chromosomal instability.
J. Cell Biol. 2001 54, 49-60

Top of page

- Return to the team home page