March 21 - 26, 2010 - Keystone Resort, Keystone, Colorado, USA
November 13, 2009
Meeting summary :
Nuclear receptors (NRs) comprise a large family of ligand-regulated transcription factors that play critical roles in physiology and disease. Much of the focus has been on the nuclear actions of NRs, including interactions with coregulators, modulation of chromatin structure, and regulation of gene expression. Recent studies, however, have also suggested a role for membrane- or cytoplasmic-initiated actions of NRs and crosstalk with other cellular signaling pathways. Current studies are aimed at understanding how the ligand-dependent molecular actions of NRs, including their subcellular localization, binding across the genome, and interaction with the proteome, connect to their roles in physiological and pathophysiological processes, including hormone-regulated cancers. In addition, NRs are being explored as targets for drug development, with many compounds on the market or in ongoing clinical trials.
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See also the joint meeting Nuclear Receptors : Development, Physiology and Disease
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