Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242) > Genome integrity and tumor biology (Scientific coordination : Valérie Schreiber) > Nuclear signalling and cancererology > Research topics > Tumour targeting
Tumour targeting strategies
One of the major goals of anti-tumour therapies is the specific addressing of inhibitor molecules to transformed cells.
In this context, we have isolated by phage-display three classes of peptides that are able to be specifically internalized in HPV transformed cell lines when they are fused to phages, proteins or viruses. These peptides have been used to develop novel vectors (viral or non-viral) specifically targeting cervical cancer cells.
The adenovirus is the most common virus used in exploratory genetic therapy projects. One of our aims is to restrain the tropism of the adenovirus to HPV transformed cells by genetic engineering (modification of the viral capsid fiber). Several strategies are developed: oncolytic virus, virus expressing interfering RNA, virus expressing gene-suicide.
At the interface of biology and chemistry, we are developing novel non-viral vectorisation strategies using cationic polymers and carbon nanotubes. These compounds are fonctionalized by chemical modifications to target and specifically eliminate cancer cells.
Molecular biology, cellular biology, phage display, recombinant adenovirus, RNA interference, carbon nanotubes, cationic polymers.
Contacts : François Deryckère. Georges Orfanoudakis.