Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242) > Receptors, membrane proteins and therapeutic innovation (Scientific coordination : Isabelle Schalk) > Membrane transport in bacteria (Isabelle Schalk) > Research topics > Iron uptake
Study of the molecular mechanisms involved in iron uptake
We investigate the various molecular mechanisms involved in iron acquisition in Pseudomonas aeruginosa.
According to its genome, this human opportunist pathogen is able to use 11 different iron uptake pathways. This redundancy illustrates the importance of iron for bacterial life. In our group, we study the uptake machinery and the regulation cascade at the molecular level in vivo and in vitro. We try to understand the molecular interactions between the proteins, their organization and distribution in the cell wall and how the resulting machine enables iron acquisition.