Partenaires

CNRS
Logo Université de Strasbourg
Logo IREBS



Rechercher

Sur ce site

Sur le Web du CNRS


Accueil > Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242)
> Receptors, membrane proteins and therapeutic innovation (Scientific coordination : Isabelle Schalk) > Membrane transport in bacteria (Isabelle Schalk) > Research topics > Innovative antibiotics

Innovative antibiotics

New targets for innovative antibiotics

Pseudomonas aeruginosa and Burkholderia cepacia cause many hospital-acquired infections and lethal infections in cystic fibrosis patients. Unfortunately, their resistance to classical antibiotics is increasing. In this context, iron uptake pathways constitute promising targets for new generations of antibiotics.

We are developing two strategies, based on the notions that iron is important for bacteria growth and that iron uptake pathways are efficient and selective.

  1. Synthesis of inhibitors of the proteins involved in iron uptake. By inhibiting some of these proteins, it may be possible to block iron acquisition by the bacteria, thereby inhibiting their proliferation.
  2. Synthesis of siderophore-antibiotic conjugates behaving like “Trojan Horses”. In this case, the siderophore transports the antibiotic into the bacteria via iron uptake pathways, and the antibiotic then kills the bacteria.

The structural and functional data generated by the biologists of the group will enable the chemists to design, synthesize and optimize new antibiotics. Each new protein studied by the biologists will also become a new potential target for antibiotics and a source of inspiration for the organic chemists of the group.

 

- Back to the research topics homepage