Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242) > Receptors, membrane proteins and therapeutic innovation (Scientific coordination : Isabelle Schalk) > Membrane transport in bacteria (Isabelle Schalk) > Research topics > Innovative antibiotics
New targets for innovative antibiotics
Pseudomonas aeruginosa and Burkholderia cepacia cause many hospital-acquired infections and lethal infections in cystic fibrosis patients. Unfortunately, their resistance to classical antibiotics is increasing. In this context, iron uptake pathways constitute promising targets for new generations of antibiotics.
We are developing two strategies, based on the notions that iron is important for bacteria growth and that iron uptake pathways are efficient and selective.
The structural and functional data generated by the biologists of the group will enable the chemists to design, synthesize and optimize new antibiotics. Each new protein studied by the biologists will also become a new potential target for antibiotics and a source of inspiration for the organic chemists of the group.