Biotechnology and cell signalling (Jean-Luc Galzi)
(UMR 7242) > Receptors, membrane proteins and therapeutic innovation (Scientific coordination : Isabelle Schalk) > Membrane transport in bacteria (Isabelle Schalk) > Research topics > Bioinspired metallophores
Biomedical applications of "bioinspired" metallophores
Nature, in several billion years of evolution, has selected molecules (siderophores) able to chelate iron highly efficiently and transport it into the cells, across membranes.
This evolutionary innovation can now be used as a source of inspiration for the synthesis of new metallophores.
These molecules may have different physicochemical properties and may therefore have many applications in biomedical fields such as cancer treatment and/or the use of iron chelators to treat the iron overload occurring in genetic diseases such as hemochromatosis, thalassemia and sickle cell disease.